Washington University of St. Louis Pediatrics Genetics & Genomics in St. Louis, Missouri
This opportunity is full-time and works approximately 40 hours per week.
Department Name/Job Location
This opportunity is in the Department of Pediatrics Genetics & Genomics and is for the Medical School Campus.
There is a research opportunity in the Pediatric Storage Disorders Laboratory of Dr. Jonathan D. Cooper. Our laboratory studies the neuronal ceroid lipofuscinoses (NCLs or Batten disease), a group of fatal genetic disorders that are profoundly neurodegenerative. The ultimate goal of our research is to develop therapeutic strategies for the treatment of the NCLs and other lysosomal storage disorders. We use a variety of different animal models to study how these diseases affect the brain and other parts of the nervous system, in addition to testing the efficacy of a range of therapeutic strategies. A lot of our work involves cutting and staining sections, followed by quantitative microscopy, but we also employ tissue culture, biochemical and molecular techniques, and study behavioral changes in our models. This is in addition to treating these models via enzyme replacement, small molecules or gene therapy, and exploring if these have altered disease outcome.
Prior experience in histology and quantitative microscopy with at least a bachelor’s degree and two or more years of research lab experience is essential. However, candidates with more years of experience, additional skills and further qualifications (including either a master’s degree and/or a PhD in relevant subjects) are also encouraged to apply.
Successful candidates will be highly motivated, independent and creative problem solvers who are open to learning new techniques.
- Experience of histological processing, immunostaining and other staining methods is essential.
- Experience of microscopy including brightfield and fluorescence applications and confocal microscopy. Image analysis and stereology experience strongly preferred.
- Experience with mouse colony management is preferable, but not essential.
- Proficiency in basic molecular biology techniques including DNA, RNA, protein isolation and purification; PCR, reverse transcription PCR, Immunoblot, and ELISA is preferable, but not essential.
- Demonstrated ability to work independently and communicate effectively.
- Should have troubleshooting skills, an ability to maintain complete and organized records, and a working knowledge of computer software and general lab equipment.
- Experience maintaining records and preparing reports.
- Excellent interpersonal skills.
Base pay commensurate with experience.
This opportunity is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Applicant Special Instructions
Works in laboratory environment with potential exposure to biological, chemical and radioactive hazards. Must be physically able to wear protective equipment. Must be able to provide standard care to research animals.
Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Job Title: Research Opportunities - Pediatrics Genetics & Genomics - 42206
Job ID: 42206
Location: Medical School
Full/Part Time: Full-Time