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Washington University of St. Louis Postdoctoral Research Associate - Bone Marrow Transplant - 49325 in St. Louis, Missouri

Post Doc Instructions

Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.

Department Name/Job Location

This position is in the Department of Internal Medicine, Division of Oncology - Bone Marrow Transplant. This position is for the Medical School Campus.

Essential Functions


Postdoctoral Research Associate position open in the Bolton Laboratory (Department of Internal Medicine, Division of Oncology).

The Bolton Lab is seeking a postdoctoral researcher to advance research in cancer genomics, with a focus on acquired pre-leukemic mutations in the blood, clonal hematopoiesis. Our group has led some of the largest and most comprehensive studies of how oncologic therapy shapes the evolution of clonal hematopoiesis and promotes its transformation to leukemia (Bolton, Nature Genetics 2020; Bolton, JCO 2020). This work has in turn informed clinical management guidelines for individuals with clonal hematopoiesis (Bolton, JCO, 2019; Steensma and Bolton, Blood 2020). The postdoctoral researcher will lead a project to characterize the dynamics of clonal hematopoiesis under oncologic therapies known to confer a high risk of secondary leukemia. Work will include analysis of targeted sequencing data, SNP array and RNA-Seq data for comprehensive characterization of genomic events. There will also be opportunities to develop additional independent projects with clinical collaborators at Washington University.

The postdoctoral researcher will have the opportunity to work within a team of clinicians, epidemiologists, bioinformaticians and statisticians within and collaborating with the Bolton laboratory. In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.


Trains under the supervision of a faculty mentor, including (but not limited to):

  1. Manages their own project, which should lead to a first author publication.
  2. Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
  3. Presents scientific work both inside and outside the University with excellent oral communication skills.
  4. Assists with grant preparation and reporting.
  5. Prepares and submits papers on research with excellent writing skills.
  6. Designs research experiments.
  7. Evaluates research findings and reports results.
  8. Maintains conscientious discharge of their research responsibilities.
  9. Maintains conformity with ethical standards in research.
  10. Maintains compliance with good laboratory practice, including the maintenance of adequate research records.
  11. Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
  12. Maintains collegial conduct towards co-trainees, staff members and members of the research group.

Required Qualifications

Ph.D., M.D. or equivalent terminal or doctoral degree.

Preferred Qualifications

  • Ph.D. in bioinformatics, statistics, mathematics, physics, or a related quantitative field.
  • Previous experience in analysis of large-scale omics data.
  • Strong programming skills in R / Bioconductor or Python.

Salary Range

Base pay commensurate with experience.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Qualified candidates should submit their CV, the names of two references, and a cover letter to Dr. Kelly Bolton (bolton@wustl.edu).

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Job Title: Postdoctoral Research Associate - Bone Marrow Transplant - 49325

Job ID: 49325

Location: Medical School

Full/Part Time: Full-Time

Regular/Temporary: Regular