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Pfizer Principal Scientist, Biophysical Chemistry in St. Louis, Missouri

We are currently hiring a Biophysical Chemist with objectives to contribute the development of life-saving medicines and to join fellow pharmaceutical scientists in supporting bioprocess development and product characterization by applying biophysical techniques. This position is based in Chesterfield, MO.


  • Explore, develop and implement electron microscopy (EM) technology, in particular cryo-EM, to characterize proteins, nucleic acids, polysaccharides, synthetic polymers, viral capsids, nanoparticles, etc. to support understanding the biotherapeutic products and bioprocess development.

  • Apply new applications and emerging technology around advanced spectroscopy, state-of-art molecular separation techniques, and other biophysical tools.

  • Interact with colleagues to provide biophysical characterization for the project teams and solve problems that contribute to process and product understanding and quality attributes.

  • Excellent communication and technical writing skills, especially in composing regulatory documents.

  • Use a high level of scientific judgment to adapt and create new analytical methodology and techniques by applying breadth of knowledge and prior work experience.

  • Mentor and coach junior scientists.

  • Identify and develop scientific activities/projects through both internal and external collaborations to support business goals.


  • PhD in physical biochemistry, analytical biochemistry, biochemistry, chemistry, or relate field, with 5+ years of post-doctoral and academic/industrial experience in working with biological molecules.

  • Strong skills and extensive experience in cryo-EM is required. Deep knowledge around EM image analysis and modeling is also required.


  • Skills and knowledge in molecular spectroscopy such as NMR, circular dichroism, vibrational spectroscopy, light scattering, etc., is highly desired.

  • Familiarity about separation technology including liquid chromatography, analytical ultracentrifugation, field flow fractionation, etc. is also desired.

  • Knowledge in polymer science, pharmaceutical sciences, statistical analysis, structural biology and molecular modeling will be considered.

  • Skills and experience in mass spectrometry, biological assays and other general analytical techniques is also desired.

Other Job Details:

  • Last Date to Apply for Job: March 31, 2021

  • Eligible for Relocation Package: YES

  • Eligible for Employee Referral Bonus: YES

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development