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Washington University of St. Louis Research Opportunities - Molecular Microbiology - 50952 in St. Louis, Missouri

Job Type/Schedule This position is full-time and works approximately 40 hours per week. Department Name/Job Location This opportunity is in the laboratory of Dr. Christina Stallings in the Department of Molecular Microbiology. This position is for the Medical School Campus. Essential Functions The Stallings Laboratory is seeking a highly motivated individual to assist with innovative research in the areas of microbiology, immunology, molecular biology, and biochemistry. In the Stallings Laboratory, we dissect the molecular details of Mycobacterium tuberculosis pathogenesis, from the perspective of both the host and the pathogen. We use a combination of genetics, biochemistry, cell biology, and animal models of disease to seek better understanding of how M. tuberculosis defends itself against host immune attacks and antibiotic therapy as well as what immune responses are required to control M. tuberculosis infection. We have identified a number of mycobacterial proteins that function as mediators of mycobacterial stress responses and are required for pathogenesis. In particular, we are currently focusing on how regulation of gene expression, DNA replication, and respiration allow M. tuberculosis to adapt to host-derived stresses and antibiotic therapy. In addition, we have discovered multiple host proteins and immune pathways that are required to control M. tuberculosis infection and prevent active tuberculosis disease. In particular, our studies highlight the importance of the innate immune response in regulating neutrophil-predominated inflammation to prevent tissue damage. In addition to these mechanistic studies, the lab is working to apply our basic science findings to the treatment of disease in humans. Required Qualifications * At least a bachelor’s degree. * Extensive prior experience in cell, molecular biology or related fields. * Hands-on work with mice (handling and monitoring mice, and performing small animal procedures). Preferred Qualifications * Experience with mammalian cell culture. * Basic microbiology skills. * Experience with flow cytometry and immunological techniques. * Proficiency in basic molecular biology techniques, including DNA, RNA, Protein isolation and purification; PCR, reverse transcription PCR, Immunoblot, ELISA. * Working knowledge of Excel, Photoshop, and Image J is a plus. * Demonstrated ability to work independently and communicate effectively. * Troubleshooting skills. * Ability to maintain complete and organized records. * Working knowledge of computer software and general lab equipment. Salary Range Base pay commensurate with experience. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Department Summary The Department of Molecular Microbiology at the Washington University School of Medicine represents one of the finest examples of an academic training in Molecular Microbiology and Infectious Diseases. Benefits This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://wustl.box.com/s/8wkhs25yssf0775x9d6nd6vqa7obpth7. Applicant Special Instructions WORKING CONDITIONS: This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals. In addition, Mycobacterium tuberculosis is handled in the Biosafety Level 3 Laboratory. EOE Statement Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. Job Title: Research Opportunities - Molecular Microbiology - 50952 Job ID: 50952 Location: Medical School Full/Part Time: Full-Time Regular/Temporary: Regular